Hemorrhagic Tumor Necrosis During a Pilot Trial of Tumor Necrosis Factor-a and Anti-GD3 Ganglioside Monoclonal Antibody
نویسندگان
چکیده
Hemorrhagic tumor necrosis is an inflammatory event that leads to selective destruction of malignant tissues, with both potentially toxic and beneficial consequences. A pilot clinical trial was undertaken combining tumor necrosis factor-a (TNF-a) with the monoclonal antibody R 2 4 (MoAb R 2 4 ) against GD3 ganglioside in patients with metastatic melanoma. Patients received MoAb R 2 4 to recruit leukocytes to the tumor followed by low doses of recombinant TNF-a to activate leukocytes. Eight patients were treated
منابع مشابه
Hemorrhagic tumor necrosis during a pilot trial of tumor necrosis factor-alpha and anti-GD3 ganglioside monoclonal antibody in patients with metastatic melanoma.
Hemorrhagic tumor necrosis is an inflammatory event that leads to selective destruction of malignant tissues, with both potentially toxic and beneficial consequences. A pilot clinical trial was undertaken combining tumor necrosis factor-alpha (TNF-alpha) with the monoclonal antibody R24 (MoAb R24) against GD3 ganglioside in patients with metastatic melanoma. Patients received MoAb R24 to recrui...
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